CBD while not psychoactive, interacts with various receptors in the ​body that can reduce inflammation and interact with ​neurotransmitter function, potentially reducing pain. CBD might also ​enhance the effects of THC, allowing for pain relief with potentially ​lower doses of THC, thus reducing psychoactive effects.

THC acts on the brain's cannabinoid receptors, which can reduce ​the perception of pain. It's known for its psychoactive effects, ​which might also contribute to a change in pain perception by ​altering mood and cognition.